distemper (n.)
malady, illness, derangement
Cym III.iv.193[Pisanio to Innogen, of a drug] a dram of this / Will drive away distemper
Ham II.ii.55[Claudius to Gertrude] The head and source of all your son's distemper
Ham III.iv.124[Gertrude to Hamlet] the heat and flame of thy distemper
TNK IV.iii.3[Gaoler to Doctor, of the Gaoler's Daughter] She is continually in a harmless distemper
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